Association between changes of gut microbiota and diseases in modern society

As shown in the illustrations on the left published on Cell, studies have well revealed that changes in gut microbiota has played critical role in many of the dramatically increasing diseases in modern society.

Our Long Term Goal

Our long term goal is to develop products for the effective treatment and prevention of these diseases by targeting the potential primary cause and root mechanism.

Our Strategy

Right now we have put onto market our first probiotic supplement after extensive screening and optimization. It showed high efficacy in the animal model of colitis and good feedback from human users. Next, we will conduct more research and develop drugs with more potent efficacy. Our strategy is from probiotics to drugs, from IBD, IBS to other health problems, and from treatment of patients to health enhancement of whole population

Some Publications on Our Studies Done So Far

Effect of bilirubin on inactivation of digestive proteases

Qin, X. Inactivation of digestive proteases by deconjugated bilirubin: the possible evolutionary driving force for bilirubin or biliverdin predominance in animals. Gut.56 (11): 1641-2, 2007.

Zhou K, Jiang M, Qin X, Wang X. Role of bilirubin in digestive proteases inactivation in the lower intestine. Dig Liver Dis 47(5):438-9, 2015.

Effect of bilirubin on gut damage in rat model of bile duct ligation

Zhou K, Jiang M, Liu Y, Qu Y, Shi G, Yang X, Qin X, Wang X. Effect of bile pigments on the compromised gut barrier function in a rat model of bile duct ligation. PLoS One 9(6):e98905, 2014.

Li X, Liu X, Zhu X, Kang F, Wang C, Fan X, Tan Y, Guo M, Qin X, Jiang M, Wang X. Unconjugated bilirubin is more effective than lithocholic acid in alleviating gut damage and dysbiosis induced by bile duct ligation in mice. Gastroenterology 160(6):S-798, 2021

Effect of bilirubin on colitis

Zhou J, Jiang M, Yang X, Liu Y, Guo J, Zheng J, Qu Y, Song Y, Li R, Qin X, g Wang X. Unconjugated bilirubin ameliorates the inflammation and digestive protease increase in TNBS-induced colitis. Mol Med Rep 16(2):1779-1784, 2017.

Zheng J, He Y, Yu H, Liu Y, Ge Y, Li X, Li X, Wang Y, Guo M, Qu Y, Qin X, Jiang M, Wang X. Unconjugated bilirubin alleviates experimental ulcerative colitis by regulating intestinal barrier function and immune inflammation. World J Gastroenterol 25(15):1865-1878, 2019.

Effect of β-glucuronidase, the enzyme needed for formation of deconjugated bilirubin, on colitis

He Y, Yu H, Ge Y, Li X, Jiang M, Liu Y, Li X, Wang Y, Guo M, Qin X, Wang X. Bacterial β-glucuronidase alleviates dextran sulfate sodium-induced colitis in mice: A possible crucial new diagnostic and therapeutic target for inflammatory bowel disease. Biochem Biophys Res Commun 513(2):426-433, 2019.

Effect of an optimized strain of probiotics on colitis

Guo M, Liu X, Tan Y, Fan X, Wang C, Kang F, Zhu X, Qin X, Wang X. An optimized strain of lactobacillus brevis on digestive proteases inactivation and colitis in mice. Digestive Disease Week, May 21 – 23, 2021 (selected as a Poster of Distinction). Published in Gastroenterology 160(6):S-714, 2021