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Xiaofa Qin. Impaired inactivation of digestive proteases by deconjugated bilirubin: the possible mechanism for inflammatory bowel disease. Med Hypotheses, 59[2]:159-63, 2002 

         Some supportive evidences published later for the above hypothesis:

• Suez, J., et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature 514(7521): 181-186, 2014.
• Edwinson, A. L., et al. Gut microbial beta-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome. Nat Microbiol 7(5): 680-694, 2022.

 Xiaofa Qin. Etiology of inflammatory bowel disease: A unified hypothesis. World J Gastroenterol, 18[15]:1708-22, 2012 

Xiaofa Qin. Changes in complex microecosystem of gut and pathogenesis of diseases in modern society - Impaired inactivation of digestive proteases may be the key event. World J Complex Med 1(1): 38-43, 2015.(An invited review published in the inaugural issue of the journal. Written in Chinese with English Abstract)